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作者对澳大利亚维多利亚地区在孕14周早期羊膜穿刺(EA)的大批量群体妇女进行随访队列研究,评估EA后的胎儿丢失率和产妇病率并和较晚期羊膜穿刺者进行比较。通过维多利亚临床遗传机构(VCGS)及围产资料收集单位(PDCV)登记进行研究。胎儿丢失率:EA研究组是1991～1992年在≤孕14周行羊膜穿刺的所有居住妇女1211例,随访1207例(随访率99.7％);比较组是1988年在15/16孕周行羊膜穿刺的1771例妇女(随访率100％)。胎儿自然丢
The authors performed a cohort cohort study of a large cohort of women at the early 14th gestational week of amniocentesis (EA) in Victoria, Australia, assessing fetal loss and maternal morbidity after EA and comparing them with those of late amniocentesis. The study was conducted through the registration of the Victorian Clinic Genetic Agency (VCGS) and the Perinatal Data Collection Unit (PDCV). Fetal loss rate: The EA study group consisted of 1211 all-resident women who underwent amniocentesis ≤ 14 weeks of gestation from 1991 to 1992, followed up for 1,207 patients (follow-up rate was 99.7%). In the comparison group, amniotic membrane Puncture of 1771 women (follow-up rate was 100%). Fetus naturally lost