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本文是有9个临床中心参加的,对大量高血压患者长期应用甲基多巴(MD)的一个回顾性研究,以评价该药的特点。本研究从3000多病人中挑出有完整记录的435病人。选出的病例必须首先以 MD 作为非利尿性抗高血压剂治疗至少1年,少于1年者除外。由于不良副反应或无效而中止治疗的患者列入本研究之中。选择研究对象的其他标准有:(1)18～75岁的原发性高血压男女患者。(2)允许在研究前或同时用利尿药治疗。也有除了 MD 外又接受非利尿性降压药治疗的病人,但仅在 MD 开始治疗之后才用。(3)在 MD 治疗前未用利尿剂者,舒张压在105至130毫米汞柱。若用利尿利,则舒张压在95至130毫米汞柱之间。(4)MD 剂量
This article is a retrospective study of long-term use of methyldopa (MD) in a large number of hypertensive patients with nine clinical trials to evaluate the characteristics of the drug. In our study, 435 patients with complete records were selected from more than 3,000 patients. Selected cases must first be treated with MD as a non-diuretic antihypertensive agent for at least 1 year, except for less than 1 year. Patients discontinued treatment due to adverse side effects or ineffective included in this study. Other criteria for selecting subjects include: (1) Men and women with essential hypertension between 18 and 75 years of age. (2) Allows diuretics to be treated before or simultaneously with the study. There are also patients who are treated with non-diuretic antihypertensive drugs in addition to MD, but only after MD is started. (3) In the absence of diuretics prior to MD treatment, diastolic blood pressure was between 105 and 130 mmHg. With diuresis, the diastolic blood pressure is between 95 and 130 mmHg. (4) MD dose