微小病变型肾病(minimal change glome-rulonephropathy,MCGN)系病理诊断名称,过去临床上称类脂性肾病。目前国内内科分类称原发性肾小球肾病,或儿科分类称单纯性肾病,估计大多数属于此种病理类型。本病多见于儿童,约占肾病综合征的70～80%,成人约占20%。本病主要特征是临床上有大量蛋白尿,而肾小球病变却极为轻微,对激素治疗极为敏感,98%病例用激索治疗能完全缓解,但容易复发。本病的发病原理长期以来未能明确。过去一段时间里,由于考虑本病有脂肪代谢紊乱的表现,如高脂血症、脂质尿和肾小管细胞有脂滴存在,曾被认为是一种代谢紊乱疾病。这种认 Minimal change glomerulonephropathy (minimal change glome-rulonephropathy, MCGN) Department of pathological diagnosis of the name, in the past clinically known as lipid-induced nephropathy. At present, the internal medical classification of primary glomerular nephropathy, or pediatric classification of simple nephropathy, it is estimated that most of these pathological types. The disease is more common in children, accounting for about 70 to 80% of nephrotic syndrome, adults account for about 20%. The main feature of this disease is clinically a large number of proteinuria, and glomerular lesions are extremely mild, extremely sensitive to hormone therapy, 98% of cases treated with lacrimal cord can be completely relieved, but easy to relapse. The pathogenesis of this disease has not been clear for a long time. Over the past period, due to consider the performance of this disease has a metabolic disorder of fat, such as hyperlipidemia, lipid droplets and tubular cells have lipid droplets, has been considered a metabolic disorder. This recognition