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目的分析对重症肌无力患者实施针灸配合糖皮质激素治疗后,对免疫球蛋白和补体的作用。方法 60例重症肌无力患者,将其随机分为对照组和观察组,各30例。对照组实施糖皮质激素治疗,观察组在对照组基础上实施针灸治疗。比较两组患者的临床疗效、免疫球蛋白G3(IgG3)、IgG1以及补体C3水平。结果观察组患者治疗有效率为96.67%(29/30),对照组为93.33%(28/30),比较差异无统计学意义(χ~2=0.3509,P>0.05)。观察组补体C3水平为(1.29±0.13)g/L,明显高于对照组的(1.08±0.05)g/L,差异有统计学意义(t=8.2581,P=0.0000<0.05)。观察组免疫球蛋白IgG3水平为(0.65±0.21)g/L,明显低于对照组的(0.91±0.15)g/L,差异有统计学意义(t=5.5182,P=0.0000<0.05)。观察组免疫球蛋白IgG1水平为(6.85±1.21)g/L,明显高于对照组的(5.72±1.15)g/L,差异有统计学意义(t=3.7077,P=0.0005<0.05)。结论对重症肌无力患者治疗时,在使用糖皮质激素治疗的基础上应用针灸配合治疗,可在起到较好治疗效果的前提下对其免疫球蛋白和补体起到更好的改进效果。
Objective To analyze the effect of acupuncture and glucocorticoid treatment on immunoglobulin and complement in patients with myasthenia gravis. Methods Sixty patients with myasthenia gravis were randomly divided into control group and observation group, 30 cases each. The control group was treated with glucocorticoid, and the observation group was treated with acupuncture on the basis of the control group. The clinical efficacy, immunoglobulin G3 (IgG3), IgG1, and complement C3 levels were compared between the two groups. Results The effective rate was 96.67% (29/30) in the observation group and 93.33% (28/30) in the control group, with no significant difference (χ ~ 2 = 0.3509, P> 0.05). The level of complement C3 in the observation group was (1.29 ± 0.13) g / L, which was significantly higher than that in the control group (1.08 ± 0.05) g / L, the difference was statistically significant (t = 8.2581, P = 0.0000 <0.05). The level of immunoglobulin IgG3 in the observation group was (0.65 ± 0.21) g / L, which was significantly lower than that in the control group (0.91 ± 0.15) g / L, the difference was statistically significant (t = 5.5182, P = 0.0000 <0.05). The level of immunoglobulin IgG1 in the observation group was (6.85 ± 1.21) g / L, which was significantly higher than that in the control group (5.72 ± 1.15) g / L, the difference was statistically significant (t = 3.7077, P = 0.0005 <0.05). Conclusion When treating patients with myasthenia gravis with acupuncture and moxibustion on the basis of glucocorticoid treatment, their immunoglobulin and complement play a better role in the treatment of myasthenia gravis.