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目的分析经皮冠状动脉介入治疗(PCI)慢性闭塞病变冠心病的效果及预后。方法选取2013年3月-2014年8月新乡市中心医院收治的慢性闭塞病变冠心病患者78例为研究对象,采用随机数表法分为观察组和对照组,各39例。对照组采用硝酸酯类、抗血小板、血管紧张素转换酶抑制剂等常规药物治疗,观察组实施PCI,术后亦给予常规药物,均治疗3个月。比较两组治疗前后每周心绞痛发作次数、6 min步行距离;采用酶联免疫吸附试验(ELISA)检测两组血管内皮生长因子(VEGF)、碱性成纤维细胞因子(b FGF)水平,并比较其左室舒张末内径(LVEDD)、左室射血分数(LVEF),同时观察不良反应发生情况。结果治疗后观察组心绞痛发作次数(0.46±0.12)次/周、LVEDD(4.72±0.23)cm,均低于对照组(均P<0.05);观察组6 min步行距离(0.56±0.10)km、VEGF(0.45±0.15)ng/ml、b FGF(0.98±0.34)ng/ml、LVEF(64.99±1.07)%,均明显高于对照组(均P<0.05);两组不良反应发生率分别为5.13%、10.26%,差异无统计学意义(P>0.05)。结论PCI治疗慢性闭塞病变冠心病效果好于保守治疗,结合常规药物可升高其VEGF、b FGF水平,且不良反应轻。
Objective To analyze the effect and prognosis of coronary artery disease in patients with chronic obstructive pulmonary disease undergoing percutaneous coronary intervention (PCI). Methods From March 2013 to August 2014, 78 patients with chronic occlusive disease and coronary heart disease admitted to Xinxiang Central Hospital were enrolled. The subjects were divided into observation group and control group with 39 cases in each group. The control group was treated with conventional drugs such as nitrates, antiplatelet and angiotensin converting enzyme inhibitors. The observation group was given PCI and the patients were given conventional drugs after operation for 3 months. The number of angina attacks per week and the walking distance of 6 min were compared between the two groups before and after treatment. The levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (b FGF) were measured by enzyme-linked immunosorbent assay (ELISA) The left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), while observing the incidence of adverse reactions. Results The number of angina attacks (0.46 ± 0.12) / LVEDD (4.72 ± 0.23) cm in observation group after treatment was lower than that in control group (all P <0.05). The distance of walking in observation group was 0.56 ± 0.10 km / The levels of VEGF (0.45 ± 0.15) ng / ml and b FGF (0.98 ± 0.34) ng / ml and LVEF (64.99 ± 1.07)% were significantly higher than those of the control group (all P <0.05) 5.13% and 10.26%, respectively, with no significant difference (P> 0.05). Conclusions The effect of PCI on chronic occlusive disease is better than that of conservative treatment. The combination of conventional drugs can increase the levels of VEGF and b FGF, and the adverse reactions are mild.