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目的 观察前列腺素E_1(PGE_1)对防治顺铂化疗肾损伤的疗效。方法 40例应用大剂量顺铂化疗的乳腺癌患者随机分为预防组和对照组,每组各20例。预防组在应用顺铂当日起,每天静点PGE_1100mg,连续7天;对照组不用PGE_1。结果 未应用PGE_1的对照组在应用顺铂后的第7天,血清尿素氮,尿微量白蛋白较用顺铂前显著升高(P<0.01和P<0.05),而应用PGE_1的预防组,应用顺铂后血清尿素氮,尿微量白蛋白变化均不明显(P>0.05)。结论 PGE_1确实有预防顺铂肾损伤的作用。
Objective To observe the efficacy of prostaglandin E_1 (PGE_1) in the prevention and treatment of cisplatin-induced renal injury. Methods Forty patients with breast cancer who received high-dose cisplatin chemotherapy were randomly divided into preventive and control groups, with 20 patients in each group. In the prevention group, PGE_1100 mg was administrated on a daily basis for 7 days from the date of application of cisplatin; PGE_1 was not used in the control group. Results In the control group without PGE_1, serum urea nitrogen and urinary microalbumin were significantly increased (P<0.01 and P<0.05) at the 7th day after cisplatin administration, and the PGE_1 prevention group was used. There was no significant change in serum urea nitrogen and urinary albumin after cisplatin administration (P>0.05). Conclusion PGE_1 does prevent cisplatin-induced renal injury.