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自古犹太和印度就用没药、胡椒、芥末、阿魏等作鼻内用药;中国在五千年以前即用麻黄。1931年Fox提出鼻内用药可能有副作用;1944年Gollum报告鼻眼净成瘾30例;1946年Lake首次提出“药物性鼻炎”命名。近期报导虽不多,但本病仍是一严重问题。作者们统计美国威斯康辛州医学院1966年7月至1976年6月耳鼻喉病例12730例中,有药物性鼻炎130例,约占1%。其中男性73例,女性57例。用药时间最短一个月、最长25年,平均21.4月。所用药物为新福林(phenylephrine)、羟间唑啉(oxymetazoline)、二甲苯间唑啉(xylometazoline);喷雾剂85例(66%),滴鼻剂33例(25%),合用者12例(9%)。调查患者自行用药的病因,
Since ancient times, the Jewish and Indian use of myrrh, pepper, mustard, ferulic, etc. for intranasal medication; China used ephedra five thousand years ago. Fox proposed in 1931 intranasal medication may have side effects; 1944 Gollum report nasal net addiction in 30 cases; 1946 Lake first proposed “drug rhinitis” name. Although there are not many recent reports, the disease is still a serious problem. The authors of the United States Wisconsin Medical College from July 1966 to June 1976 12,730 cases of otolaryngology, drug-induced rhinitis in 130 cases, accounting for about 1%. 73 males and 57 females. The shortest one month medication, the longest 25 years, an average of 21.4 months. The drugs used were phenylephrine, oxymetazoline and xylometazoline; 85 (66%) sprays, 33 nasal drops (25%), and 12 (9%). Investigate the etiology of patients with their own medication,