路易小体是帕金森病的重要病理特征,近年来发现路易小体中包含多种成分如α-共核蛋白、parkin及UCH-L1等,在帕金森病发生和发展的不同阶段这些成分具有不同病理特征及生化组成,提示路易小体的形成与帕金森病发病机制密切相关。本文就该方面的研究进展做一文献综述。 Lewy bodies is an important pathological feature of Parkinson’s disease. In recent years, it has been found that Lewy bodies contain many components such as α-synuclein, parkin, UCH-L1 and so on. These components have different roles in the development and progression of Parkinson’s disease Different pathological features and biochemical composition, suggesting that the formation of Lewy bodies is closely related to the pathogenesis of Parkinson’s disease. This article makes a literature review on the research progress in this area.