论文部分内容阅读
系统性红斑狼疮（ SLE）病程多为慢性、反复发作并进行性加重的过程，常伴有不同脏器功能的损害。目前，多采用糖皮质激素、免疫抑制剂等药物进行全身性治疗。然而，长期用药往往会造成不良反应的累积，加之疾病的进展，使脏器受损不断加重。对重症SLE患者而言，主要脏器受损则更加明显，不但治疗困难，而且预后较差。随着治疗观念的改变，对重症SLE患者不同靶器官受累情况进行评估和有针对性的个体化治疗，不仅可以更好地控制 SLE的病情活动，还可以减少药物的不良反应，使得重症SLE患者的预后得到明显改善。“,”Systemic lupus erythematosus( SLE) has a course of chronic recurrent attacks and progressive deterioration,and is often accompanied by critical organs damage.Currently,the patients are mostly treated with glucocorticosteroid and immunosuppressive agents.The critical organs are uninterruptedly impaired by the long-term accumulation of adverse drug reaction and the progression of disease.Severe SLE has an unfavourable prognosis,because the critical organs are impaired seriously and the treatment is difficult.Along with the changing of the concept of treatmnet,the tailored assessment and treatment of target organs involved in severe SLE not only improves the therapeutic effect but also reduces the adverse drug reaction,therefore an evidently improved prognosis can be expected.