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目的研究脑梗死患者急性期血清 IL -6、IL-8、TNF-α、IL -1β水平的变化 ,特别是 IL -6水平与脑梗死面积及神经功能缺损的关系。方法采用双抗体夹心 ELISA法检测 3 4例脑梗死急性期患者不同时间内血清 IL-6、IL -8、TNF-α、IL -1β水平 ,并随机抽取 10例健康人进行对照。结果脑梗死患者血清 IL -6水平在发病 6小时内明显升高 ,2 4～ 3 6小时达高峰 ,7天后基本降至正常 ,大面积梗死组IL-6水平明显高于小面积梗死组 ( 6小时内 ,P <0 .0 5 ;2 4～ 3 6小时 ,P <0 .0 5 ) ,且血清 IL -6水平与神经功能评分呈正相关( r=0 .87,P<0 .0 1) ,七叶皂甙钠治疗 3天后血清 IL-6水平下降明显 ( P<0 .0 1) ,脑梗死患者急性期血清 IL-8水平亦升高( P<0 .0 5 ) ,TNF-α、IL-1β水平则无明显变化。结论急性脑梗死患者血清 IL-6水平升高 ,而 IL-6升高的水平反映应激反应程度 ,与梗死面积及神经功能缺损程度有一定相关性。
Objective To study the changes of serum levels of IL-6, IL-8, TNF-α and IL-1β in patients with acute cerebral infarction, especially the relationship between IL-6 and cerebral infarction area and neurological deficits. Methods Serum levels of IL-6, IL-8, TNF-α and IL-1β in 34 acute cerebral infarction patients at different time points were detected by double antibody sandwich ELISA. Ten healthy controls were randomly selected. Results Serum levels of IL-6 in patients with cerebral infarction were significantly increased within 6 hours after onset, peaked at 24 to 36 hours and dropped to normal after 7 days. The level of IL-6 in large infarction group was significantly higher than that in small infarction group 6 hours, P <0. 05; 2 4 ~ 36 hours, P <0. 05), and serum IL-6 levels were positively correlated with neurological score (r = 0.87, P < 1), serum IL-6 level decreased significantly after 3 days of aescine treatment (P <0.01), and the level of IL-8 in acute phase of cerebral infarction was also increased (P <0.05). The level of TNF- α, IL-1β levels did not change significantly. Conclusions Serum IL-6 levels are elevated in patients with acute cerebral infarction. The elevated level of IL-6 reflects the degree of stress response, which is related to the infarct size and the degree of neurological deficit.