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[目的]比较根除幽门螺杆菌(Hp)的标准三联疗法与序贯疗法的疗效。[方法]120例Hp感染者随机分为序贯疗法组、标准三联疗法组。序贯疗法组:口服奥美拉唑40mg(2次/d)+克拉霉素500mg(2次/d)共5d,继之用奥美拉唑40mg(2次/d)+阿莫西林1.0g(2次/d)+呋喃唑酮100mg(2次/d)共5d;标准三联疗法组:口服奥美拉唑40mg(2次/d)+阿莫西林1.0g(2次/d)+克拉霉素500mg(2次/d)共10d。2组治疗结束后至少停药4周复查13 C尿素气试验,≤4%为Hp阴性,表示根除成功,同时评估疗效及安全性。[结果]序贯疗法组Hp根除率为93.3%;标准三联疗法组Hp根除率为81.7%;2组Hp根除率比较差异有统计学意义(P<0.05)。[结论]根除Hp的序贯疗法明显优于标准三联疗法。
[Objective] To compare the efficacy of standard triple therapy and sequential therapy for the eradication of Helicobacter pylori (Hp). [Method] 120 cases of Hp infection were randomly divided into sequential therapy group and standard triple therapy group. In the sequential therapy group, omeprazole 40 mg (twice daily) and clarithromycin 500 mg twice daily for 5 days followed by omeprazole 40 mg twice daily plus amoxicillin 1.0 (2 times / d) + furazolidone 100mg (2 times / d) for 5 days; standard triple therapy group: Omeprazole 40mg (2 times / d) + amoxicillin 1.0g 500mg (2 times / d) for 10 days. At least 4 weeks after discontinuation of the treatment, the 13 C urea gas test was performed in both groups, and ≤4% was negative for Hp, indicating that the eradication was successful and the efficacy and safety were also evaluated. [Result] The Hp eradication rate was 93.3% in the sequential therapy group and 81.7% in the standard triple therapy group. The Hp eradication rate in the two groups was significantly different (P <0.05). [Conclusion] The sequential therapy of Hp eradication is obviously better than the standard triple therapy.