We should grasp the entirety when studying the pathogenesis and treatment of disease.The pathogenesis of SLE pafients with atherosclerosis (AS)involves lipid infiltration,inflammatory reaction,immune injury,platelet aggregafion,thrombosis,etc,and the drug therapy includes lipid-lowering,anti-inflammatory,immunosuppression,anti-platelet,and anticoagulation based on corresponding theories.But these drugs,the effect of which is not ideal,principally aim at just part of pathological process.In fact,the AS lesioas in SLE in different pathological processes are closely linked,and therefore,it is very important to study the internal relations of different pathological processes and lookfor new therapeutic targets for blocking difierent pathological processes simultaneously,so as to improve the therapeutic efficacy.