本文目的在于探讨氯氮平是否比其它抗精神病药更易引起体重增加及其发生机理。入组者均为病情稳定期的门诊病人,符合DSM--R慢性精神分裂症标准及神经阻滞剂治疗有效者,随机接受氟哌啶醇或氯氮平进行为期10周的平行、双盲试验治疗,氟哌啶醇与氯氮平的平均剂量分别是每日24.8mg± The purpose of this paper is to investigate whether clozapine more likely causes weight gain and its underlying mechanisms than other antipsychotics. Participants were outpatients with stable disease, who were eligible for DSM - R criteria for chronic schizophrenia and treated with nerve blockers. Patients were randomized to receive either haloperidol or clozapine for 10 weeks in a parallel, double - blind Experimental treatment, the average dose of haloperidol and clozapine 24.8mg daily ±