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用石蜡切片、HE染色进行图像分析研究了22例15~40周受精龄胎肝造血细胞发育过程。结果表明,15周胎肝未见明显的造血干细胞;16~20周时造血细胞数量达到最高峰,以后随着胎龄的增大,造血细胞逐渐增少;但足月胎肝仍见造血细胞,这说明胎儿出生后肝可能维持一段时间的造血功能。本研究为胚胎学发育积累资料,亦为临床选择胎肝制成活细胞悬液治疗再生障碍性贫血提供了参考。
Paraffin sections and HE staining were used to analyze the development of hepatic hematopoietic cells in 22 fetuses aged from 15 to 40 weeks. The results showed that no significant hematopoietic stem cells were found in fetal liver at 15 weeks. The number of hematopoietic cells peaked at 16 ~ 20 weeks, then gradually increased with the increase of gestational age, but hematopoietic cells were still seen in term fetal liver , Indicating that the fetus after the liver may maintain a period of hematopoietic function. This study accumulates data for the development of embryology and provides a reference for the treatment of aplastic anemia by selecting the live cell suspension made from fetal liver.