细胞素(cytokins)是炎症、脓毒症和多器官功能衰竭的介质,属于起局部作用的蛋白质激素,由多种细胞所产生,如肿瘤坏死因子(TNF)、白细胞介素、干扰素、菌落刺激因子、淋巴因子和单核细胞因子等。外科实践中也无例外地涉及到细胞素这一问题。肿瘤坏死因子有两种,即TNF-a和TNF-b,前者是巨噬细胞受刺激后生成的多肽类产物,在脓毒症和恶性肿瘤患者的血清中其值明显增高;后者又称淋巴毒素,由T细胞经特异抗原刺激后产生,其量少。本文重点介绍前一种。TNF可使肿瘤的新生血管塌陷而致肿瘤出血性坏死,还可引起类似细菌和内毒素所致的综合征。如事先给予TNF单克隆抗体免疫处理, Cytokins are mediators of inflammation, sepsis and multiple organ failure and are localized protein hormones that are produced by a variety of cells, such as tumor necrosis factor (TNF), interleukins, interferons, colonies Stimulating factors, lymphokines and monocytes and so on. Surgical practice is no exception related to the issue of cytokines. Tumor necrosis factor, there are two, namely TNF-a and TNF-b, the former is macrophage stimulated polypeptide products produced in patients with sepsis and malignant tumor serum was significantly higher; the latter also known as Lymphotoxin, produced by T cells stimulated by specific antigens, in small amounts. This article focuses on the former. TNF can cause tumor neovasculature collapse resulting in tumor hemorrhagic necrosis can also cause similar bacterial and endotoxin-induced syndrome. If given prior to immunization of TNF monoclonal antibody,