200例活动期十二指肠球部溃疡病人随机分为两组,分别采用国产哌仑西平150mg/天和西米替丁1.0g/天口服治疗,疗程4周,并进行胃镜复查。两组溃疡愈合率分别为53％和60％,疼痛消失率分别为80％和76％,无显著差异。哌仑西平组的主要副作用为口干和视物模糊,分别为59％和35％,程度较轻,不影响治疗,未见肝肾功能和造血系统的不良影响。西米替丁组有4例 GPT 轻度增高。 200 cases of active duodenal ulcer patients were randomly divided into two groups were treated with domestic pirenzepine 150mg / day and cimetidine 1.0g / day oral treatment, the course of 4 weeks, and the gastroscope review. The ulcer healing rates in both groups were 53% and 60%, respectively, and the rates of pain disappearance were 80% and 76% respectively, with no significant difference. The main side effects of pirenzepine were dry mouth and blurred vision, which were 59% and 35%, respectively, to a lesser extent without any effect on treatment, with no adverse effects on liver and kidney function and hematopoietic system. In the cimetidine group, 4 patients had mild GPT.