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血红蛋白病的免疫学诊断,已往曾有不少学者探索研究。Heller和Chernoff原想用免疫学方法诊断HbS,HbC等异常血红蛋白,后发现HbA和HbS的特异性很差,不能应用。Schneider等发现HbF与HbH,Barts有交叉免疫反应的现象。但Wasi应用较纯和大量的Hb Barts,使免疫产生抗体而供作诊断应用。虽然HbF含有γ_2肽链,但在他的试验观察中,Hb Barts(γ_4)与HbF并无交叉免疫反应,认为特异性是较高的。我们的经验亦未看到交叉免疫反应现象。看来Hb Barts免疫学诊断,是目前比较敏感可用的方法,仅因Hb Barts难于取得而不易推广制备应用。我们在本地区因遇到Hb Barts胎儿水肿综合征,
Hemoglobin disease immunological diagnosis, there have been many scholars to explore the past. Heller and Chernoff originally wanted to use immunological methods to diagnose HbS, HbC and other abnormal hemoglobin, and found that the specificity of HbA and HbS is poor and can not be applied. Schneider found that HbF and HbH, Barts cross-immune reaction phenomenon. But Wasi uses purer and larger amounts of Hb Barts, which immunize antibodies for diagnostic purposes. Although HbF contains a γ_2 peptide chain, Hb Barts (γ_4) did not cross-react with HbF in his experimental observations, suggesting that the specificity is high. Our experience also did not see the phenomenon of cross-immune reaction. It appears that immunological diagnosis of Hb Barts, is currently more sensitive to the available method, simply because of Hb Barts difficult to obtain and not easy to promote the preparation of applications. We encountered Hb Barts fetal edema syndrome in the region,