巨噬细胞(Mφ)是免疫反应中重要的调节细胞,作为辅助细胞它表达和呈递自身Ia抗原给自身反应性L_3T_4~+T 细胞,Mφ(Ia)-T 细胞间的作用是T 细胞调节的第一信号。Mφ还释放一些可溶性因子对自身免疫反应进行正向或负向调节。但荷瘤宿主(TBH)Mφ)的辅助能力降低。作者用8～12周雄性BALB/c 小鼠脾L_3T_4~+T 细胞和脾Mφ做体外自身混合淋巴细胞反应(AMLR)研究TBH Macrophage (Mφ) is an important regulatory cell in immune response. As a helper cell, it expresses and presents its own Ia antigen to autoreactive L_3T_4 ~ + T cells. The role of Mφ (Ia) -T cells is T cell regulation First signal. Mφ also releases some soluble factors that regulate the autoimmune response either positively or negatively. However, the ability of the tumor-bearing host (TBH) Mφ) was reduced. The authors used an in vitro autologous mixed lymphocyte reaction (AMLR) study of TBH in spleen L_3T_4 ~ + T cells and splenic Mφ in male BALB / c mice aged 8-12 weeks