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在内侧颞叶癫痫(mTLE)中,内侧颞叶与皮层及皮层下结构参与了癫痫活动的起源与传播。基于Granger因果性(GC)检验方法,对脑电联合功能磁共振(EEG-fMRI)数据进行分析,研究内侧颞叶在mTLE中的作用。以内侧颞叶激活区域为参考区域,计算参考区域与大脑其余每个体素点之间的Granger因果关系,并映射到全脑,形成Granger因果图(GCM)。结果表明,内侧颞叶将癫痫活动传播到外侧颞叶、额叶、顶叶及丘脑等区域,同时受到脑岛、壳核以及丘脑等区域脑活动的影响,提示内侧颞叶在mTLE痫样发放的传播环路中具有关键作用。
In medial temporal lobe epilepsy (mTLE), medial temporal lobe and cortical and subcortical structures are involved in the origin and transmission of epileptic activity. EEG-fMRI data were analyzed based on Granger causality (GC) test to investigate the role of medial temporal lobe in mTLE. Using the medial temporal lobe activation region as a reference region, Granger causality between the reference region and each of the remaining brain voxels was calculated and mapped to the whole brain to form a Granger causality map (GCM). The results showed that the medial temporal lobe transmitted the epileptic activity to lateral temporal lobe, frontal lobe, parietal lobe and thalamus, and was also affected by brain activity in the insula, putamen and thalamus, suggesting that medial temporal lobe was distributed in mTLE The transmission loop has a key role.