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[目的]探讨因胃癌行全胃切除术患者的临床病理特点及其预后的影响因素。[方法]回顾分析1989年1月￣2003年5月因胃癌行全胃切除术504例患者的临床及病理资料,结合随访资料进行单因素和多因素分析。[结果]全组504例胃癌患者的1、3、5年生存率分别为58.3%、37.3%、21.8%。胃癌根治术、扩大根治术和非根治术的5年生存率分别为40.0%、23.6%和16.3%。经单因素和COX回归分析,胃癌患者行全胃切除术预后的独立影响因素为淋巴结转移、脏器侵犯、肿瘤部位、浸润深度和Borrmann分型。[结论]选择合适的淋巴结清扫范围,进行合理的联合脏器切除,对改善因胃癌行全胃切除患者的预后有重要意义。
[Objective] To investigate the clinicopathological features and prognostic factors of patients undergoing total gastrectomy for gastric cancer. [Methods] The clinical and pathological data of 504 patients undergone total gastrectomy for gastric cancer from January 1989 to May 2003 were retrospectively analyzed. Univariate and multivariate analysis were performed with follow-up data. [Results] The 1, 3, 5-year survival rates of 504 patients with gastric cancer were 58.3%, 37.3% and 21.8% respectively. The 5-year survival rates of radical gastrectomy, extended radical gastrectomy and non-radical gastrectomy were 40.0%, 23.6% and 16.3% respectively. By single factor and COX regression analysis, the independent prognostic factors of gastrectomy in patients with gastric cancer were lymph node metastasis, organ invasion, tumor location, depth of invasion and Borrmann classification. [Conclusion] Choosing the appropriate range of lymph node dissection and performing reasonable organ resection is of great significance in improving the prognosis of patients undergoing total gastrectomy for gastric cancer.