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目的探讨胰岛素增敏剂对多囊卵巢综合征(PCOS)的治疗效果。方法随机选择PCOS患者66例,分为A、B两组,分别给予二甲双胍、罗格列酮治疗3个月,检测患者治疗前及治疗后3个月的血清血脂、血糖、胰岛素以及雄激素等指标,观察月经变化和排卵情况。结果两种方法治疗后均可不同程度的改善痤疮、减少多毛、恢复月经、促进排卵及妊娠,使雄激素水平明显下降,但两组之间差异无统计学意义。结论胰岛素增敏剂治疗可以改善PCOS患者高雄激素血症、无排卵,恢复规律月经、甚至自然妊娠,长期服用可以降低以后发生糖尿病、高血压、高脂血症、冠心病的发病危险,可能是合并胰岛素抵抗(IR)的PCOS患者理想的治疗方法。
Objective To investigate the therapeutic effect of insulin sensitizer on polycystic ovary syndrome (PCOS). Methods Sixty-six PCOS patients were randomly selected and divided into A and B groups. Metformin and rosiglitazone were given respectively for 3 months. Serum lipids, blood glucose, insulin and androgen levels were measured before and 3 months after treatment Indicators, observation of menstrual changes and ovulation. Results Both treatments improved acne, decreased hirsutism, restored menstruation, promoted ovulation and pregnancy, and significantly decreased androgen levels after treatment. However, there was no significant difference between the two groups. Conclusions Insulin sensitizer treatment can improve hyperandrogenism, ovulation-free, regular menstruation and even natural pregnancy in PCOS patients. Long-term use of insulin sensitizer can reduce the risk of developing diabetes, hypertension, hyperlipidemia and coronary heart disease later, which may be The ideal treatment for PCOS with insulin resistance (IR).