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目的研究抗菌药物不同给药途径对金双歧预防急性化脓性扁桃体炎患儿抗生素相关性腹泻的影响,为临床合理利用金双歧辅助治疗提供依据。方法选取崇州市人民医院2013年1月至2014年7月开展的“金双歧辅助治疗儿童扁桃体炎的疗效研究”科研项目中试验组患儿85例,观察其在住院期间(静脉使用抗菌药物期间)和出院后期间(口服抗菌药物期间)抗生素相关性腹泻的发生,两期间均口服金双歧预防抗生素相关性腹泻。结果静脉使用抗菌药物期间8例患儿发生抗生素相关性腹泻,发生率为9.41%;口服抗菌药物期间1例患儿发生抗生素相关性腹泻,发生率为1.18%。两期间比较差异具有统计学意义(χ2=5.749,P=0.016)。结论静脉使用抗菌药物比口服抗菌药物对金双歧的抑制和杀灭作用影响大,使金双歧预防继发性腹泻的能力减弱或消失。
Objective To study the effects of different administration routes of antimicrobial agents on the antibiotic-associated diarrhea in children with acute suppurative tonsillitis, so as to provide basis for clinical use of Jinshanqi adjuvant therapy. Methods From January 2013 to July 2014, Chongzhou Municipal People’s Hospital conducted “Golden Bifidobacterium Assisted Therapy of Acute Tonsillitis in Children.” In the research project, 85 children in the experimental group were observed during hospitalization (intravenous antibiotics Period), and antibiotic-associated diarrhea during and after discharge (oral antibacterials), both of which were administered oral bifidobacterium to prevent antibiotic-associated diarrhea. Results Antibiotic-related diarrhea occurred in 8 infants during the intravenous antibacterial period, with an incidence rate of 9.41%. One antibiotic-associated diarrhea occurred in 1 patient during oral administration of antibiotics, with a prevalence of 1.18%. The difference between the two groups was statistically significant (χ2 = 5.749, P = 0.016). Conclusions Intravenous antibacterials have a greater effect on the inhibition and killing of bifidobacteria than oral antibacterial agents, and their ability to prevent secondary diarrhea diminishes or disappears.