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本实验研究了从Ｓｐｒａｇｕｅ－Ｄａｗｌｅｙ大鼠红细胞中提取的抗高血压因子（ａｎｔｉｈｙｐｅｒｔｅｎｓｉｖｅｆａｃｔｏｒ，ＡＨＦ）对苯肾上腺素引起的Ｗｉｓｔａｒ大鼠胸主动脉螺旋条预收缩的舒张作用。结果表明：ＡＨＦ对主动脉条的舒张呈内皮与剂量依赖性。左旋硝基精氨酸与美蓝均可阻断ＡＨＦ的舒血管作用，而铜锌超氧化物歧化酶对ＡＨＦ的舒血管效应有促进作用。提示ＡＨＦ是通过刺激内皮细胞产生一氧化氨或其类似物，从而激活血管平滑肌细胞内可溶性鸟苷酸环化酶这一途径引起血管舒张的。
This study investigated the antihypertensive factor (AHF) extracted from erythrocytes of Sprague-Dawley rats to attenuate the precontraction of phenylephrine induced Wistar rat thoracic aorta. The results showed that: AHF aortic strips dilated endothelium and dose-dependent. Both L-nitroarginine and methylene blue blocked the vasodilator effect of AHF, whereas copper-zinc superoxide dismutase promoted the vasodilator effect of AHF. Tip AHF by stimulating endothelial cells to produce ammonia or its analogues, thereby activating the vascular smooth muscle cells within the pathway of soluble guanylate cyclase induced vasodilation.