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由于越来越多的证据支持肿瘤干细胞假说,研究者们也开始设想卵巢癌也可能是干细胞失调所致的疾病[1]。已有研究证实,人类卵巢中的一小群细胞具有干细胞样特性,这些细胞与卵巢癌干细胞一样都具有自我更新能力和不定向分化潜能,以及相似的生长调控机制和转移的潜能[2]。另外,干细胞的寿命相对于普通卵巢癌细胞长,这就使得干细胞有足够长的时间累积致瘤性突变,最终导致正常干细胞的恶性转化。1卵巢癌干细胞
As more and more evidence supports the cancer stem cell hypothesis, researchers also began to envision that ovarian cancer may also be a disorder caused by stem cell dysfunction [1]. Studies have shown that a small group of cells in the human ovary have stem cell-like properties. These cells, like ovarian cancer stem cells, have the potential for self-renewal and non-directional differentiation as well as similar growth regulatory mechanisms and metastatic potentials [2]. In addition, the lifespan of stem cells is longer relative to that of normal ovarian cancer cells, which allows stem cells to accumulate tumorigenic mutations long enough to eventually lead to the malignant transformation of normal stem cells. 1 ovarian cancer stem cells