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本文报告1例系统性红斑狼疮(SLE)患者服甲氰咪胍(cimetidine)后引起皮肤狼疮加重。患者女性,63岁,有关节痛和弥慢性关节肿胀史20年,面部偶发日光过敏性皮疹和手指新近出现雷诺氏现象。体检发现面部有局限性红斑。面部损害活检显示表皮基底层液化变性和沿真皮表皮交界处有免疫球蛋白沉淀,与 LE 相符。抗核抗体(ANA)阳性(1:640)。患者曾因消化性溃疡而作过迷走神经切断术和幽门成形术。1980年3月,患者上腹部持续不
This article reports a case of systemic lupus erythematosus (SLE) patients with cimetidine (cimetidine) caused by increased skin lupus. A 63-year-old female patient with a history of arthralgia and diffuse chronic joint swelling of 20 years had a recent Raynaud’s phenomenon with an allergic skin rash on her face and fingers. Physical examination revealed a limited facial erythema. Facial lesion biopsy revealed liquefaction of the basal layer of liquefaction and immunoglobulin precipitation along the dermal junction, consistent with LE. Antinuclear antibody (ANA) positive (1: 640). Patients have had vagotomy and pyloroplasty due to peptic ulcers. March 1980, the patient continued on the abdomen not