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近年来,电子显微镜研究揭示耳蜗毛细胞存在两种突触,一种是毛细胞特别是外毛细胞与耳蜗传出纤维(COCB)形成突触,另一种则是耳蜗传入神经纤维主要与内毛细胞(95％)形成突触。电刺激COCB,引起CM振幅增大,AP(N_1)振幅减小,目前已有工作证明耳蜗传出神经末梢与毛细胞之间的传递递质可能为乙酰胆碱(ACh),ACh耳蜗内灌流摸拟实验得到与电刺激COCB同样的效果。 然而,目前耳蜗传入突触递质为何物尚不清楚。最近,用催化萤光测量技术揭示,耳蜗内淋巴液中含有较多谷氨酸和天冬氨
In recent years, electron microscopy revealed two synapses of cochlear hair cells, one is the hair cells, especially the outer hair cells and the cochlear outgoing fibers (COCB) to form synapse, the other is the cochlear afferent nerve fibers mainly Internal hair cells (95%) form synapses. Electrical stimulation of COCB induces an increase in CM amplitude and a decrease in amplitude of AP (N_1). At present, it has been demonstrated that the transmission neurotransmitter between cochlear nerve terminals and hair cells may be acetylcholine (ACh), ACh cochlear perfusion Experiment and electrical stimulation COCB the same effect. However, it is unclear what current cochlear afferent synaptic transmission occurs. Recently, catalytic fluorimetry revealed that intracochlear lymphatic fluid contains more glutamate and aspartate