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乙醇影响许多药物的药效,为引起临床重视,摘要介绍如下。 1维生素类药物 乙醇可减少VB_1的吸收,严重肝硬化嗜酒者,肝脏不能将硫胺素转变为活性形式,慢性酒精中毒者常伴有VB_1缺乏症。乙醇损害胃粘膜及肝功能可阻碍VB_(12)的吸收和转化。 2解热镇痛药 乙醇与水杨酸钠共用,可增加药物抑制胃肠孺动,收缩粘膜血管,引起局部缺血,坏死、粘膜糜烂及出血等副作用。乙醇还能抑制扑热息痛的排泄,使体内毒物增加。若同时使用超剂量的扑热息痛,可引起严重的肝昏迷或肝坏死,甚至导致急性肾衰竭致死。
Ethanol affects the efficacy of many drugs, to attract clinical attention, summarized as follows. 1 vitamin drugs can reduce the absorption of VB_1 ethanol, alcoholic liver cirrhosis, the liver can not be converted to active form of thiamine, chronic alcoholism are often accompanied by VB_1 deficiency. Ethanol damage gastric mucosa and liver function can hinder VB_ (12) absorption and transformation. 2 antipyretic analgesics ethanol and sodium salicylate sharing can increase the inhibition of gastrointestinal motility, contraction of mucosal blood vessels, causing ischemia, necrosis, mucosal erosion and bleeding and other side effects. Ethanol can also inhibit excretion of paracetamol, so that the body increased poisoning. If you use overdose of paracetamol at the same time, can cause severe hepatic coma or liver necrosis, and even lead to death in acute renal failure.