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目的 探讨妊高征（ＰＩＨ）中一氧化氮（ＮＯ）与胎盘绒毛超微结构的关系。方法 用硝酸根还原酶法测定６２ 例ＰＩＨ孕妇（分轻、中、重度３ 组） 和３５ 例正常孕妇（正常组） 的血清ＮＯ，用硝酸甘油治疗８ 例重度ＰＩＨ，观察其血清ＮＯ的变化，并选择２０ 例（各组５ 例） 胎盘行透射电镜检查。结果 ＰＩＨ 组ＮＯ低于正常组，且随着病情加重而逐渐降低； 轻度ＰＩＨ 与正常的胎盘绒毛超微结构无差异，中重度则明显异常；用硝酸甘油后ＮＯ 明显增加，胎盘超微结构无明显改善。结论 ＮＯ降低到一定程度才能导致胎盘绒毛超微结构不可逆的改变，并互相影响；从临床意义看硝酸甘油治疗重度ＰＩＨ疗效肯定，但并未产生质的改善。
Objective To investigate the relationship between nitric oxide (NO) and the ultrastructure of placenta villi in pregnancy induced hypertension (PIH). Methods Serum NO was measured by nitrate reductase in 62 cases of PIH pregnant women (subgroups with mild, moderate and severe) and 35 normal pregnant women (normal group). Eight cases of severe PIH were treated with nitroglycerin. The changes of serum NO Twenty patients (5 in each group) underwent transmission electron microscopy. Results NO in PIH group was lower than that in normal group and decreased with the severity of illness. The ultrastructure of placenta villi in mild PIH was not different from that in normal placenta, No significant improvement. Conclusion NO reduced to a certain extent can lead to irreversible changes in the ultrastructure of placental villi, and affect each other; from a clinical point of view, nitroglycerin treatment of severe PIH positive effect, but did not produce qualitative improvement.