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目的通过对照研究,区分大剂量分割时总治疗时间对局控率的影响。方法 2000年9月至2010年9月,152例初次接受放疗的T1声门癌患者进行根治性放疗,放疗剂量为65Gy/26f,每天1次,每周4次,每周剂量为10Gy,并根据治疗时间(OTT)的不同,将病人分为2组:OTT≤46 d和OTT≥47 d,总生存率(OS)和局控率(LC)用Kaplan-Meier方法计算,统计学差异运用Log-rank法。结果 3年和5年的OS分别是93.4%和88.8%,3年和5年的LC分别是90.8%和86.7%,OTT≥47 d的患者3年和5年的LC分别为82.1%和78.6%,OTT≤46 d的患者3年和5年的LC分别为95.8和91.7%,2组的5年LC差异有统计学意义(p=0.018)。结论总治疗时间是影响局控率的重要因素,治疗时间越短,局控率越高。
OBJECTIVE: To compare the effect of total treatment time on the rate of local control during high-dose fractionation through a controlled study. Methods From September 2000 to September 2010, 152 patients with initial radiotherapy of T1 glottic cancer underwent radical radiotherapy at a dose of 65 Gy / 26 f once daily for 4 times a week at a dose of 10 Gy per week The patients were divided into two groups according to the treatment time (OTT): OTT≤46d and OTT≥47d. The overall survival rate (OS) and local control rate (LC) were calculated by Kaplan-Meier method. Log-rank method. Results The 3-year and 5-year OS were 93.4% and 88.8%, respectively. The 3-year and 5-year LC were 90.8% and 86.7% respectively. The 3-and 5-year LCs were 82.1% and 78.6 The patients with OTT ≤46d had LC of 95.8% and 91.7% at 3 years and 5 years, respectively. There was significant difference between the 2 groups in 5 years LC (p = 0.018). Conclusion The total treatment time is an important factor affecting the control rate. The shorter the treatment time, the higher the control rate.