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为了探索青蒿琥酯治疗恶性疟的适宜剂量,本文设五个不同剂量组进行比较。其中三天总量:A组8mg/kg、B组6mg/kg、C组4mg/kg、D组2mg/kg、E组1mg/kg。结果表明,D、E两组分别有3/5人,5/8人6天原虫不转阴,提示剂量不足;而A、B、C三个剂量组所有病人原虫6天内均转阴,平均清除95％原虫所需的时间均为16小时,平均退热时数约20小时,平均原虫转阴时数约60小时,三组无明显差异。为了便于不同年龄组的药量计算,初步推荐青蒿琥酯治疗恶性疟的适宜剂量为三天总量4.8mg/kg,对原虫严重感染者(感染率≥6％),首剂加倍。
In order to explore the appropriate dose of artesunate in the treatment of falciparum malaria, five different dose groups were compared in this study. The total amount of three days was 8 mg/kg in group A, 6 mg/kg in group B, 4 mg/kg in group C, 2 mg/kg in group D, and 1 mg/kg in group E. The results showed that there were 3/5 people in groups D and E, 5/8 of 6-day protozoa did not turn negative, suggesting that the dose was insufficient; and the protozoa of all patients in groups A, B, and C were negative in 6 days. The time required for removing 95% of the protozoa was 16 hours, the average number of hours of fever was about 20 hours, and the average number of protozoa was about 60 hours. There was no significant difference between the three groups. In order to facilitate the calculation of drug dosages in different age groups, it is initially recommended that the appropriate dose of artesunate for the treatment of falciparum malaria is 4.8 mg/kg for three days, and the first dose is doubled for serious infections of the protozoa (infection rate ≥ 6%).