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作用于丝氨酸/苏氨酸蛋白质磷酸酶(PPs)是细胞功能和神经变性过程中重要的调节物质。已经证明PPs的抑制与谷氨酸诱导的神经细胞死亡有相同的神经毒性作用,但可拮抗雌激素介导的神经保护作用。该研究主要探讨冈田酸(OA)抑制磷酸酶而诱导的神经毒性机制。当神经元暴露于OA或者是
Serine / threonine protein phosphatases (PPs) are important regulators of cellular and neurodegeneration. Inhibition of PPs has been shown to have the same neurotoxic effects as glutamate-induced neuronal cell death but to antagonize estrogen-mediated neuroprotective effects. This study mainly focused on the neurotoxicity induced by okadaic acid (OA). When neurons are exposed to OA or yes