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目的 :探讨慢性扁桃体炎患儿扁桃体隐窝上皮的变化。方法 :将摘除的 2 30例扁桃体均以 10 %福尔马林固定 ,常规石蜡包埋切片 ,HE染色 ,并行抗隐窝上皮角质蛋白 (CK)免疫组化检测 ,观察小儿慢性扁桃体炎症变化。结果 :2 30例扁桃体隐窝上皮明显角化 2 0 9例 (90 .9% ) ,未见角化 2 1例 (9.1% ) ;3例隐窝底部有霉菌菌丝和细菌 ;扁桃体隐窝上皮抗广谱和高分子 CK均呈阳性反应 ,全组隐窝内角化物抗广谱 CK亦均呈阳性反应。结论 :小儿扁桃体每次炎症病变 ,都使扁桃体上皮进行性破坏 ,扁桃体产生免疫球蛋白的物质减少 ,因而不能有效发挥保护作用 ,而细菌、病毒等物质却可顺利通过化生性上皮向上皮下侵犯 ,这种周而复始的恶性循环 ,只有施行扁桃体切除术方能阻断
Objective: To investigate the changes of amygdala epithelium in children with chronic tonsillitis. Methods: Totally 30 tons of tonsils were fixed in 10% formalin, paraffin embedded sections were made and stained with hematoxylin and eosin (HE). The anti-crypt epithelial keratin (CK) immunohistochemistry was used to detect the changes of chronic tonsillitis in children. Results: Twenty cases of tonsil crypt epithelial keratosis were found to be keratinized (90.9%) and 21 cases (9.1%) were not keratinized. The mycotic fungus and bacteria were found in the bottom of 3 crypts, Epithelial anti-broad-spectrum and macromolecular CK were positive reaction, the whole group of crypts within the broad-spectrum CK also showed a positive response. CONCLUSIONS: Every inflamed tonsil undergoes progressive destruction of the amygdaloid epithelium and tonsils produce reduced immunoglobulin, thus failing to effectively exert its protective effect. However, bacteria, viruses and the like can be successfully infringed into the epithelium through the metaplastic epithelium, This vicious cycle of recurrence, only the implementation of tonsillectomy can block