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本文观察了二甲基亚砜对家兔脊髓实验性损伤的早期疗效。治疗组动物后肢运动功能的恢复明显较对照组好,无大小便障碍,手术切除之椎板已被新生骨组织所修复,对照组动物大部分不能恢复后肢运动功能,伤口有明显水肿及炎症,切除之椎板亦无修复。治疗组损伤之脊髓段含水量明显较对照组少(治疗组含水28%,对照组含水42%,P<0.0025),神经元形态较为正常,其新陈代谢旺盛,正常细胞数较对照组多,P=0.01,有核分裂现象。对照组轴突周围间隙明显较治疗组扩大、纤维横断面积大于治疗组,P<0.00025。本实验表明二甲基亚砜对早期脊髓损伤有较好的疗效、能减轻组织水肿、保护神经组织、促进脊髓功能恢复和组织修复,并对二甲基亚砜的作用机制、进行了初步讨论。
This article observed the early effects of dimethyl sulfoxide on experimental spinal cord injury in rabbits. The recovery of motor function of the hindlimbs of the treated animals was significantly better than that of the control group. No defecation disorder was found. The lamina of the surgical resection had been repaired by the new bone tissue. Most of the animals in the control group could not recover the motor function of the hind limbs, and the wounds had obvious edema and inflammation. The excised lamina had no repair. The water content of spinal cord injury in the treatment group was significantly lower than that in the control group (28% in the treatment group, 42% in the control group, P<0.0025), and the morphology of the neurons was normal. The metabolism was strong and the number of normal cells was more than that in the control group. = 0.01, there is nuclear fission. The gap around the axon was significantly larger in the control group than in the treatment group, and the fiber cross-sectional area was larger than the treatment group, P<0.00025. This experiment shows that dimethyl sulfoxide has a good effect on early spinal cord injury, can reduce tissue edema, protect nerve tissue, promote spinal cord function recovery and tissue repair, and discussed the mechanism of dimethyl sulfoxide, preliminary discussion .