A series of 2’-purine and pyrimidine derivatives of 1’ ,4’-anhy-dro-2’-deoxy-D-arabitol (1) and 1’, 4’-anhydro-2’-deoxy-D-altritol (2) were synthesized regio- and stereo-selectively from D-sorbitol through some conversion in high yields. A series of 2’-purine and pyrimidine derivatives of 1 ’, 4’-anhy-dro-2’-deoxy-D-arabitol (1) and 1’, 4’-anhydro-2’-deoxy-D-altritol 2) were synthesized regio- and stereo-selectively from D-sorbitol through some conversion in high yields.