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近年来发现蓖麻毒素中B链除具有细胞结合作用外,还有促进A链杀伤效应的功能。作者用完整蓖麻毒素制备B链半乳糖基结合位点封闭的胃癌McAb免疫毒素,发现这种免疫毒素对胃癌细胞具有高度选择性杀伤作用;由于这种免疫毒素的作用较A链免毒疫素增强,故认为免疫毒素中B链的存在有助于增强A链的细胞杀伤作用。
In recent years, ricin toxin B chain found in addition to cell binding, but also to promote the role of A chain killing effect. The author uses intact ricin to prepare the McAb immunotoxin of gastric cancer with B-galactosyl binding site and found that this immunotoxin has a highly selective killing effect on gastric cancer cells. Due to the effect of this immunotoxin on A-chain immunization Prime enhanced, it is believed that the presence of B chain immunotoxin contribute to enhance the A chain cell killing.