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目的观察阿德福韦酯联合中药治疗乙肝病毒相关性肾炎的临床疗效。方法 60例乙肝病毒相关性肾炎患者随机分为两组,两组均根据患者具体临床表现予以对症治疗,如降压、利尿、抗感染、输注人体血浆白蛋白等,肝功能有损害者,予以护肝治疗;对照组予阿德福韦酯,治疗组在对照组基础上加服自拟中药。治疗6个月后观察疗效。结果治疗组临床疗效明显优于对照组(P<0.05);两组治疗前后24h尿蛋白,谷丙转氨酶(ALT)、血浆白蛋白(ALB)、尿素氮(BUN)、肌酐(Scr)均得到了较明显的改善(P<0.05),且治疗组治疗后以上指标的改善明显优于对照组(P<0.05);治疗组治疗后HBV-DNA转阴率明显优于对照组(P<0.05)。结论阿德福韦酯联合中药治疗乙肝病毒相关性肾炎疗效显著。
Objective To observe the clinical efficacy of adefovir dipivoxil combined with traditional Chinese medicine in the treatment of hepatitis B virus associated nephritis. Methods Sixty patients with hepatitis B virus-associated nephritis were randomly divided into two groups. Patients in both groups were given symptomatic treatment according to their specific clinical manifestations such as hypotension, diuretic, anti-infective, infusion of human plasma albumin, liver damage, To liver protection; control group to adefovir dipivoxil, the treatment group in the control group plus serving Chinese medicine. After 6 months of treatment, the curative effect was observed. Results The clinical efficacy of the treatment group was significantly better than that of the control group (P <0.05). The levels of urinary protein, ALT, ALB, BUN and Scr before and after treatment in both groups were (P <0.05), and the improvement of the above indexes in the treatment group was obviously better than that in the control group (P <0.05). After treatment, the negative rate of HBV-DNA in the treatment group was obviously better than that in the control group ). Conclusion Adefovir dipivoxil combined with traditional Chinese medicine treatment of hepatitis B virus-associated nephritis significant effect.