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目的 探讨浆液性卵巢癌染色体畸变与预后关系。方法 直接法分析97例浆液性卵巢癌体腔液或瘤内细胞G带梁色体。结果 复杂畸变组49例，生存率极显著低于48例简单畸变者（P＜0．001）。21例带瘤存活者中复杂畸变检出率71．43％，极显著高于无瘤存活者中的18．18％（P＜0．001）。11个变量经COX模型多因素分析显示，化疗前后总染色体结果有独立预后意义（P＜0．001），而病理分级可能有独立预后意义（P＝0．053）。23例化疗前后动态观察显示，化疗后畸变细胞比例升值率极显著负相关于生存期（r＝－0．5786，P＜0．005）。结论 浆液性卵巢癌复杂染色体畸变可作为独立的不良预后因素；化疗前后动态染色体将有助于卵巢癌个体化预后评价。
Objective To investigate the relationship between chromosomal aberrations and prognosis in serous ovarian cancer. Methods Direct analysis of 97 cases of serous ovarian cancer fluid or tumor cells with G-banding beam body. Results 49 cases of complex distortion group, the survival rate was significantly lower than 48 cases of simple aberrations (P <0.001). The detection rate of complex aberrations in 21 cases with tumor survivors was 71.43%, which was significantly higher than 18.18% of those without tumor survivors (P <0.001). The multivariate analysis of 11 variables by COX model showed that the results of total chromosome before and after chemotherapy had independent prognostic significance (P <0.001), but the pathological grade may have independent prognostic significance (P = 0.053). The dynamic observation of 23 cases before and after chemotherapy showed that the proportion of abnormal cells after chemotherapy was significantly negatively correlated with the survival rate (r = -0.5786, P <0.005). Conclusion The complex chromosomal aberrations in serous ovarian cancer can be regarded as an independent prognostic factor. The dynamic chromosomes before and after chemotherapy will contribute to the individualized prognosis evaluation of ovarian cancer.