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目的:探讨补佳乐联合复方氨维胶囊对子宫内膜厚度及妊娠率的影响。方法:经B超监测有排卵发生但子宫内膜厚度<7 mm的不孕患者,随机分为补佳乐组(月经第7日给予补佳乐至排卵后2周)、氨基酸组(以复方氨维胶囊代替补佳乐)及联合用药(同时服用补佳乐和复方氨维胶囊)组,观察内膜生长情况及妊娠率。结果:共纳入患者142例,补佳乐组46例,氨基酸组48例,联合用药组48例,3组患者用药后子宫内膜厚度均较服药前增加(6.11±0.62 mmvs 8.03±1.34 mm、6.09±0.57 mm vs 7.94±1.28 mm、6.08±0.76 mm vs 8.93±1.47 mm),差异均显著(P<0.05)。联合用药组服药前、后的子宫内膜增加幅度及妊娠率均高于补佳乐组及氨基酸组,差异显著(P<0.05)。结论:复方氨维胶囊联合补佳乐可一定程度提高子宫内膜厚度,有助于胚胎着床,增加妊娠率,从而改善妊娠结局。
Objective: To investigate the effect of nadrogloxacin combined with compound Ammo capsule on endometrial thickness and pregnancy rate. Methods: The infertile patients who had ovulation but whose endometrial thickness was less than 7 mm were randomly divided into nocturnal music group (nociception on the 7th day for 2 weeks after ovulation), amino acid group Ammonia capsules instead of naloxone) and combination therapy (taking Jiajin Le and compound ammonia capsules) group, observe the growth of endometrial and pregnancy rate. Results: A total of 142 patients were included in the study, 46 patients in the nocturnal group, 48 patients in the amino acid group and 48 patients in the combination group. The thickness of the endometrium in the three groups was significantly higher than that before treatment (6.11 ± 0.62 mm vs 8.03 ± 1.34 mm, 6.09 ± 0.57 mm vs 7.94 ± 1.28 mm, 6.08 ± 0.76 mm vs 8.93 ± 1.47 mm, respectively) (P <0.05). The increase rate of the endometrium and the pregnancy rate in the combination group before and after taking the drug were higher than those in the nociceptin group and the amino acid group, with significant difference (P <0.05). CONCLUSION: The combination of compound Ammo capsule and norepinephrine can increase the thickness of endometrium to a certain extent, help embryo implantation, increase pregnancy rate and improve pregnancy outcome.