The interaction between high temperature creep and low cycle fatigue in an Fe-25Ni-15Cr basedalloy GH132 has been studied under three different loading schedules: (a) continuous cycliccreep, (b) prior creep followed by fatigue, and (c) prior fatigue followed by creep. It is found thatthe interaction appears nearly linear for all the three schedules. The behaviour of interactionin GH132 alloy is different from that previously observed in a GH30 alloy (Nimonic 75 type),in which although the interaction at schedules (a) and (c) was linear, a pronounced negativeinteraction occurred at the schedule (b), i.e., prior creep followed by fatigue. This differenceis found to be associated with the difference in the evolution of microstructure. In the GH132alloy, no cell structure is formed during the tests. while in the GH30 alloy, cell structure is welldeveloped during prior creep, which impedes the motion of dislocations during sequential fatigue,resulting in a negative interaction between creep and fatigue. The interaction between high temperature creep and low cycle fatigue in an Fe-25Ni-15Cr basedalloy GH132 has been studied under three different loading schedules: (a) continuous cycliccreep, (b) prior creep followed by fatigue, and (c) prior fatigue followed The behavior of interaction in GH132 alloy is different from that previously observed in a GH30 alloy (Nimonic 75 type), in which although the interaction at schedules (a) and This difference was found in be associated with the difference in the evolution of microstructure. In the GH132alloy, no cell structure is formed during the tests. while in the GH30 alloy, cell structure is welldeveloped during prior creep, which impedes the motion of dislocations during sequential fatigue, resulting in a negative interaction between creep and fatigue