EML4-ALK融合基因阳性非小细胞肺癌

来源 :国际肿瘤学杂志 | 被引量 : 0次 | 上传用户：wormchen

【摘要】

：

EML4-ALK基因融合能提高间变性淋巴瘤激酶(ALK)表达水平,激活ALK引起的肿瘤细胞生长、增殖、抗凋亡.EML4-ALK基因融合阳性肺癌常见于不吸烟的年轻女性腺癌患者,有着独特的临

【作者】

：

黄晓琳曹子昂

【机构】

：

上海交通大学医学院附属仁济医院胸外科

【出处】

：

国际肿瘤学杂志

【发表日期】

：

2004年期

【关键词】

：

癌非小细胞肺基因融合分子诊断技术 Carcinoma non-small-cell lung Gene fusion Molecular diagnost

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EML4-ALK基因融合能提高间变性淋巴瘤激酶(ALK)表达水平,激活ALK引起的肿瘤细胞生长、增殖、抗凋亡.EML4-ALK基因融合阳性肺癌常见于不吸烟的年轻女性腺癌患者,有着独特的临床特征.目前检测EML4-ALK融合基因常用方法有逆转录聚合酶链式反应技术、原位杂交免疫荧光和免疫组化技术.ALK抑制剂克卓替尼能够作用于该基因的传导通路并抑制其肿瘤活性.

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EML4-ALK融合基因阳性非小细胞肺癌

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