目的探讨胎儿脉络丛囊肿产前诊断的临床意义及处理原则。方法对我院2004年5月至2007年3月孕中期经 B 超诊断的55例胎儿脉络丛囊肿孕妇纳入研究,分别进行孕期胎儿染色体核型检查、B 超观察囊肿变化及消失时间、随访母儿结局。结果 55例胎儿脉络丛囊肿均在孕16～25周经 B 超诊断,囊肿直径0.2～2.4 cm,双侧25例、单侧30例;孤立性脉络丛囊肿50例、复杂性脉络丛囊肿5例。除5例引产外,44例囊肿在孕26周前消失,孕28周前全部消失。在50例胎儿染色体核型检查中,诊断18三体2例,21三体1例,5例未查染色体核型的胎儿出生后身体检查及随访1年未见异常。5例因伴发胎儿结构或染色体异常行中期引产,1例产后随访发现新生儿心脏室间隔缺损。此6例中,3例为高龄孕妇、5例合并胎儿结构畸形、5例为双侧或单侧脉络丛囊肿直径>1.0 cm。结论 (1)胎儿脉络丛囊肿可在孕中期经 B 超诊断,多在孕28周前自行消失。(2)孕妇高龄、合并胎儿超声结构异常及双侧或单侧脉络丛囊肿直径>1.0 cm,为染色体异常的高危因素,建议行胎儿染色体核型检查。 Objective To investigate the clinical significance and principles of prenatal diagnosis of fetal choroid cyst. Methods 55 pregnant women with fetal choroid plexus cysts diagnosed by B-ultrasound during the second trimester of pregnancy from May 2004 to March 2007 in our hospital were enrolled in this study. Fetal chromosome karyotype examination was performed during pregnancy, cyst changes and disappearance time were observed by B ultrasound. Children’s ending. Results 55 cases of fetal choroid plexus cysts were diagnosed by B-mode ultrasonography at 16-25 weeks gestation. The diameters of cysts were 0.2-2.4 cm, 25 cases were bilateral and 30 cases were unilateral. There were 50 cases of solitary choroid plexus and complex choroid plexus 5 example. In addition to 5 cases of induced labor, 44 cases of cysts disappeared 26 weeks before pregnancy, all disappeared 28 weeks before pregnancy. In 50 cases of fetal karyotype examination, diagnosis of 18 trisomy 18 cases, trisomy 21 cases, 5 cases of unmarried chromosome karyotype fetus after birth, physical examination and follow-up 1 year showed no abnormalities. Five cases had mid-term induction of labor due to fetal structure or chromosomal abnormalities. One case of postpartum follow-up found neonatal ventricular septal defect. Among the 6 cases, 3 were advanced pregnant women, 5 had fetal structural malformations, and 5 had bilateral or unilateral choroid plexus cysts> 1.0 cm in diameter. Conclusions (1) Fetal choroid cyst may be diagnosed by B-ultrasound in the second trimester, and disappear by itself more than 28 weeks before pregnancy. (2) The age of pregnant women, combined with fetal ultrasound structural abnormalities and bilateral or unilateral choroid plexus cyst diameter> 1.0 cm, is a risk factor for chromosomal abnormalities, it is recommended line fetus chromosome karyotype examination.