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刚地弓形虫是一种广泛寄生在人和动物的细胞内寄生原虫。人因食入含有包囊或卵囊的食物或水而感染,亦可经胎盘垂直感染胎儿。刚地弓形虫感染对神经系统的损伤可以表现为各种精神异常,比如参与人自杀倾向的形成;同时也与多种精神疾病的发病有关,如精神分裂症、狂躁症等。本文通过对近几年相关文献的阅读,综述刚地弓形虫感染与自杀倾向、精神分裂症、狂躁症、自闭症以及阿尔兹海默症等几种精神疾病之间的关系及其可能的致病分子机制,呈现刚地弓形虫与几项主要精神疾病的研究成果。
Toxoplasma gondii is a parasitic parasite that widely parasites in humans and animals. Infected by food or water containing cysts or oocysts and infection, but also through the placenta vertical infection of the fetus. Toxoplasma gondii infection of the nervous system damage can be manifested as a variety of mental disorders, such as participants in the formation of suicidal tendency; but also with a variety of mental illness related to the incidence, such as schizophrenia, mania and so on. This article reviews the related literatures in recent years and summarizes the relationship between Toxoplasma gondii infection and several mental diseases such as suicidal tendency, schizophrenia, mania, autism and Alzheimer’s disease and its possible Pathogenic molecular mechanism, showing Toxoplasma gondii and several major mental diseases research results.