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用放射免疫分析法观察电离辐射对大鼠组织内α2-巨球蛋白(α2M)含量的影响。一组大鼠8313.5Gy ~(60)Goγ线全身照射,在照后一周内观察各组织中α2M含量变化。结果表明:电离辐钳后,尤其是照后第7天,组织内α2M含量显著上升,肝脏、骨髓、肾脏、皮肤、腮腺和脾脏内α2M含量分别为对照组的25.67、25.11、14.79、11.22、11.22和6.46倍。另一组大鼠7.0Gy~(60)C0γ线全身照射,在照后四周内观察α2M在皮肤中变化情况。结果表明:皮肤内α2M含量在照后第1天即见上升,至第7天达高峰,以后逐渐下降,至第21天接近正常水平,但至第28天又见上升。比较两组实验结果,可发现随着照射剂量的增加,皮肤内α2M含量变化加大。
The effect of ionizing radiation on the content of α2-macroglobulin (α2M) in rat tissues was observed by radioimmunoassay. One group of rats received whole body irradiation with 8313.5Gy ~ (60) Goγ line, and the changes of α2M content in each tissue were observed within one week after irradiation. The results showed that after ionizing splint clamp, especially on the 7th day after irradiation, the content of α2M in the tissue increased significantly. The content of α2M in the liver, bone marrow, kidney, skin, parotid gland, and spleen was 25.67, 25.11, 14.79, and 11.22, respectively, in the control group. 11.22 and 6.46 times. Another group of rats was irradiated with 7.0 Gy 60 COS line, and the changes of α2M in the skin were observed within four weeks after irradiation. The results showed that the content of α2M in the skin increased on the first day after exposure, peaked on the seventh day, then decreased gradually, and reached the normal level on the 21st day, but increased again on the 28th day. Comparing the experimental results of the two groups, it can be found that as the irradiation dose increases, the α2M content in the skin increases.