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目的探讨甲亢性周期性瘫痪的发病机制、临床特点及诊治。方法对32例甲亢性周期性瘫痪患者的临床资料进行回顾性分析。结果男性29例,女性3例。周期性瘫痪发作时均有四肢或双下肢无力或软瘫;发作时均有血钾降低,T3和T4高于正常。给予补钾及抗甲亢治疗后症状消失。结论甲亢性周期性瘫痪的发病可能与自身免疫、钾代谢紊乱有关,男性多见,易反复发作,休息或补钾后症状缓解,抗甲状腺治疗是控制甲亢性周期性瘫痪复发的关键。
Objective To investigate the pathogenesis, clinical features and diagnosis and treatment of hyperthyroidism periodic paralysis. Methods The clinical data of 32 patients with hyperthyroidism periodic paralysis were analyzed retrospectively. Results 29 males and 3 females. Cyclical paralysis both limbs or both lower extremity weakness or soft paralysis; seizures have decreased serum potassium, T3 and T4 higher than normal. Give potassium and anti-hyperthyroidism symptoms disappear. Conclusions The incidence of hyperthyroidism periodic paralysis may be related to the autoimmune and disorder of potassium metabolism. It is common in men and easy to recurrent, and the symptoms are relieved after rest or potassium supplement. Anti-thyroid treatment is the key to control recurrence of cyclical paralysis of hyperthyroidism.