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目的分析幽门螺杆菌(Hp)感染与胃癌前病变、胃癌的关系。方法对6年中门诊胃镜检查的106 780例患者进行快速尿素酶试验检测Hp,并结合活检病理报告,对Hp感染与年龄、胃癌前病变、胃癌进行回顾性统计分析。结果 Hp感染率由2006年的36.3%降至2011年的24.2%。20-29岁组Hp感染率为34.9%,明显高于40-49岁组的31.4%、50-59岁组的28.5%和>60岁组的24.8%(P<0.05)。6年中,Hp感染患者中肠化生、胃癌发生率均明显下降(P<0.05),高级别上皮内瘤变发生率明显上升(P<0.05)。肠化生、上皮内瘤变、胃癌患者中Hp感染率均显著下降(P<0.05)。结论 6年间胃镜检查患者中Hp感染率逐年下降,Hp感染在青中年中居多,胃癌前病变及胃癌患者的Hp感染率下降。
Objective To analyze the relationship between Helicobacter pylori (Hp) infection and gastric precancerous lesions and gastric cancer. Methods A total of 106,780 patients undergoing endoscopy in 6 years underwent rapid urease test for detection of Hp. Hp infection and age, gastric precancerous lesions and gastric cancer were analyzed retrospectively with biopsy results. Results The infection rate of Hp dropped from 36.3% in 2006 to 24.2% in 2011. Hp infection rate was 34.9% in 20-29 years old group, significantly higher than 31.4% in 40-49 years old group, 28.5% in 50-59 years old group and 24.8% (P <0.05)> 60 years old group. In 6 years, the incidence of metaplasia and gastric cancer in Hp infection patients were significantly decreased (P <0.05), and the incidence of high-grade intraepithelial neoplasia was significantly increased (P <0.05). Intestinal metaplasia, intraepithelial neoplasia, gastric cancer patients Hp infection rates were significantly decreased (P <0.05). Conclusion The incidence of Hp infection in patients undergoing endoscopy decreased year by year in six years. The prevalence of Hp infection in young middle-aged patients was lower than that in patients with gastric precancerous lesions and gastric cancer.