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目的研究ｒａｓｐ２１，ｐ５３癌基因蛋白产物在眼眶横纹肌肉瘤（ＲＭＳ）中的表达及其与预后的关系。方法对确诊的２１例眼眶ＲＭＳ用免疫组化ＡＢＣ法标记ｒａｓｐ２１，ｐ５３蛋白。结果发现ｒａｓｐ２１，ｐ５３在眼眶ＲＭＳ的阳性率分别为４２．９％和７６．２％。随访的１３例患者中，ｐ５３阳性表达组１００％预后不好，ｒａｓｐ２１／ｐ５３阳性表达组８０％预后不好，ｒａｓｐ２１／ｐ５３阴性组２５％预后不好。阳性组和阴性组之间有显著性差异（Ｐ＜０．０５）。结论ｒａｓｐ２１，ｐ５３蛋白表达可判断预后，而ｐ５３更为敏感，是肿瘤预后差的重要指标之一。
Objective To study the expression of rasp21 and p53 oncogene protein in orbital rhabdomyosarcoma (RMS) and its relationship with prognosis. Methods 21 cases of orbital RMS were identified by immunohistochemical ABC method labeled rasp21, p53 protein. The positive rates of rasp21 and p53 in orbital RMS were 42.9% and 76.2% respectively. Among the 13 patients who were followed up, 100% of patients with positive p53 expression had poor prognosis, 80% of patients with positive expression of rasp21 / p53 had poor prognosis, and 25% had poor prognosis with rasp21 / p53 negative patients. There was a significant difference between positive group and negative group (P <0.05). Conclusion The expression of rasp21 and p53 can be used as a prognostic marker, and p53 is more sensitive, which is one of the most important prognostic factors in the prognosis of the patients.