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目的探讨甲氨蝶呤与来氟米特联用治疗类风湿性关节炎的临床效果。方法选择我院2013年7月~2014年7月收治的120例类风湿性关节炎患者为研究对象,将其随机分为观察组和对照组,每组各60例。给予对照组患者单一甲氨喋呤治疗,给予观察组患者甲氨蝶呤与来氟米特联用治疗,比较两组患者的治疗效果。结果观察组总有效率(93.3%)高于对照组(81.7%),两组数据差异明显,具有统计学意义(P<0.05)。观察组不良反应的发生率(8.3%)与对照组不良反应的发生率(10.0%)相比较,差异不显著,未见明显统计学意义(P>0.05)。结论甲氨蝶呤与来氟米特联用治疗类风湿性关节炎效果显著,具有安全性和可靠性,对改善患者的病情,促进患者康复具有重要作用。
Objective To investigate the clinical effect of methotrexate combined with leflunomide in the treatment of rheumatoid arthritis. Methods A total of 120 patients with rheumatoid arthritis who were treated in our hospital from July 2013 to July 2014 were randomly divided into observation group and control group, with 60 cases in each group. Patients in the control group were treated with methotrexate alone and methotrexate combined with leflunomide in the observation group. The therapeutic effect was compared between the two groups. Results The total effective rate (93.3%) in the observation group was higher than that in the control group (81.7%). There was significant difference between the two groups (P <0.05). The incidence of adverse reactions in the observation group (8.3%) was not significantly different from the incidence of adverse reactions in the control group (10.0%), with no significant difference (P> 0.05). Conclusion Combination of methotrexate and leflunomide treatment of rheumatoid arthritis significant effect, with safety and reliability, to improve the patient’s condition, promote patient rehabilitation plays an important role.