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目的探讨小剂量环磷酰胺(CTX)联合霉酚酸酯(MMF)治疗系统性红斑狼疮(SLE)的临床疗效,旨在为SLE的治疗提供新的思路。方法选取2012年1月至2016年3月平顶山市第一人民医院收治的SLE患者98例,将患者随机分为两组,各49例。两组均给予激素治疗,在此基础上,对照组采用传统环磷酰胺(CTX)治疗,而观察组采用环磷酰胺(CTX)联合霉酚酸酯(MMF)治疗。比较两组治疗前、治疗6个月后血清白蛋白、尿蛋白定量、肌酐、抗ds-DNA抗体水平及不良反应发生率。结果两组治疗6个月后血清白蛋白高于治疗前,尿蛋白定量、肌酐、抗ds-DNA抗体明显低于治疗前,差异有统计学意义(P<0.05);两组间治疗前及治疗6个月后血清白蛋白、尿蛋白定量、肌酐等相比,差异无统计学意义(P>0.05);观察组不良反应发生率较对照组明显降低,差异有统计学意义(P<0.05)。结论小剂量CTX联合MMF治疗SLE疗效确切,且不良反应发生率更低,安全性更高。
Objective To investigate the clinical efficacy of low dose cyclophosphamide (CTX) combined with mycophenolate mofetil (MMF) in the treatment of systemic lupus erythematosus (SLE) and to provide new ideas for the treatment of SLE. Methods From January 2012 to March 2016, 98 patients with SLE admitted to the First People’s Hospital of Pingdingshan City were selected and randomly divided into two groups (49 cases each). Both groups were given hormone therapy. On this basis, the control group was treated with traditional cyclophosphamide (CTX), and the observation group was treated with CTX combined with mycophenolate mofetil (MMF). Serum albumin, urinary protein, creatinine, anti-ds-DNA antibody levels and incidence of adverse reactions were compared between the two groups before treatment and 6 months after treatment. Results After 6 months treatment, serum albumin was higher than before treatment. Urine protein, creatinine and anti-ds-DNA antibody were significantly lower than those before treatment (P <0.05) Compared with the control group, the incidence of adverse reactions in the observation group was significantly lower than that in the control group (P <0.05), and there was no significant difference in serum albumin, urine protein and creatinine after 6 months of treatment (P> 0.05) ). Conclusion Low-dose CTX combined with MMF is effective in treating SLE with lower incidence of adverse reactions and higher safety.