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对４０例重症肺感染患者血清肿瘤坏死因子（ＴＮＦ）水平进行放免测定，并与４０例正常人进行对照。结果显示：肺感染患者血清ＴＮＦ处于高水平状态，与正常人相比有极显著性差异（Ｐ＜０．００１）；１０例患者治疗２周后血清ＴＮＦ水平较治疗前明显降低（Ｐ＜０．０５）。提示肺感染时机体释放过量的ＴＮＦ，参与炎症所致的急性肺损伤过程；血清中ＴＮＦ水平能反映肺部感染状态及病情变化。作者认为：对血清ＴＮＦ水平，特别是对肺泡灌洗液中ＴＮＦ含量变化及其与其它细胞因子相互作用的研究，可为重症肺感染患者的治疗开辟新的途径
Serum levels of tumor necrosis factor (TNF) were measured by radioimmunoassay in 40 patients with severe pulmonary infection and compared with 40 healthy controls. The results showed that the level of serum TNF in patients with pulmonary infection was significantly higher than that in healthy people (P <0.001), and the level of serum TNF was significantly decreased in 10 patients 2 weeks after treatment (P <0 .05). It is suggested that the body releases excessive TNF during lung infection and is involved in the process of acute lung injury caused by inflammation. The level of TNF in serum can reflect the status of lung infection and the change of disease. The authors suggest that a new approach to the treatment of patients with severe lung infections may be to study the changes of serum TNF levels, especially the changes of TNF levels in bronchoalveolar lavage fluid and their interaction with other cytokines