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有机磷酸酯类(下称有机磷)的中毒,是医疗工作中较为常见的病例。有机磷因抑制体内胆碱酯酶的活性,导致体内乙酰胆碱的蓄积而出现毒性。常用解毒剂有阿托品和肟类化合物(解磷定、氯磷定等)。笔者根据治疗工作的实践,结合临床药学,在使用以上解毒剂过程中,对两个问题提出讨论并浅谈我们的体会。一、有机磷中毒及其解救机理有机磷入体后,与体内胆碱酯酶结合,形成磷酰化酶而失去水解乙酰胆碱的作用,乙酰胆碱体内的蓄积,导致中枢神经系统、植物神经和运动神经的中毒症状。
Poisoning of organophosphates (hereinafter referred to as organophosphorus) is a more common case of medical work. Organic phosphorus due to the inhibition of cholinesterase activity in vivo, leading to the accumulation of acetylcholine in vivo toxicity. Common antidotes are atropine and oxime compounds (Phosphate, Chloride, etc.). The author based on the practice of the treatment work, combined with clinical pharmacy, in the process of using the above antidote, two questions to discuss and talk about our experience. First, the organophosphate poisoning and its rescue mechanism Organophosphorus into the body, with the body of cholinesterase, phosphorylase formation of the role of the loss of hydrolysis of acetylcholine, acetylcholine accumulation in the body, leading to the central nervous system, autonomic nervous system and exercise Nerve poisoning symptoms.